Fagpressenytt

M.Sc Anna Frida Forsberg at Institute of Basic Medical Sciences defended the thesis “Modulation of nuclear lamin-chromatin interactions by external cues" for the degree of PhD (Philosophiae Doctor) on the 4th May 2020. The work was carried out under supervision of Professor Philippe Collas, University of Oslo.

The three-dimensional (3D) organization of chromatin in the mammalian cell nucleus plays an important role in the regulation of gene expression. In her Ph.D. thesis, Anna Frida Forsberg has investigated the impact of distinct stimuli on how structural proteins of the nucleus, A- and B-type lamins, participate in 3D genome organization. Identification of genome domains interacting with A- and B-type lamins by chromatin immunoprecipitation shows that in liver cancer cells, A- and B-type l