NBS-nytt
27.11.2017
Since the late 1980s, starting with Professor Ingolf Nes and coworkers, scientists at Ås have focused on research involving bacteriocin purification, genetics, gene expression and mode of action studies. Increasingly, bacteriocin projects at Ås are now being directed at practical goals such as developing them as drugs to inhibit antibiotic resistant pathogens.
Bacteriocins are small antimicrobial peptides (30-60 amino acids) produced by bacteria that are usually active against related bacterial species but not against eukaryotic cells. First discovered in E. coli, bacteriocins occur among both Gram-negative (for example, E. coli and Pseudomonas aeruginosa) and Gram-positive bacteria (for example, Lactobacillus and Lactococcus spp. ).
Although different bacteriocins have different specificities, all of them apparently act by targeting specific membrane receptors at picoto nanomolar concentrations, causing membrane-disruption and pore formatio
Gå til medietAlthough different bacteriocins have different specificities, all of them apparently act by targeting specific membrane receptors at picoto nanomolar concentrations, causing membrane-disruption and pore formatio
